Pilot study on drug resistance of  Mycobacterium tuberculosis in  Xi’an city, Shaanxi province, China

Objective　By drug susceptibility testing of clinical isolated Mycobacterium tuberculosis (M.TB) to four first line anti TB trugs, to know the situation of drug resistant Shaanxi epidemic M.TB strains,provide a foundation for tuberculosis clinical treatment. Methods　Clinical isolated M.TB strains were tested with absolute concentration method.And the types were identified by differential medium culture method. Results　Among 104 clinical isolated M.TB strains,71 strains were sensitive to four first line anti TB trugs(SM, RFP, INH, EMB; 68.3%), 33 strains were drug resistant (31.7%). Among drug resistant strains,12 strains were single drug resistant, muti drug resistant strain was 21.104 M.TB were 24.0%,18.7%, 16.3% and 2.9% to resistant INH, RFP, SM and EMB respectively. Conclusion　Clinical isolated M.TB of Shaanxi is very serious on drug resistant. Drug resistant TB should be give a sufficiency attention.