Investigation of mosquito-borne flavivirus infection in part areas of Xinjiang Uygur autonomous region

Objective To investigate the infection status and spatial distribution of mosquitoes-borne flavivirus among the cases of fever with unknown origin in Xinjiang, China. Methods A total of 641 serum samples were collected from the cases of fever with unknown origin in Kashi, southern Xinjiang and in Yili, northern Xinjiang. The IgM antibodies to Japanese encephalitis virus, dengue virus and West Nile virus were detected by ELISA and the parallel neutralization tests of the 3 viruses were conducted for positive samples. Results The positive rate for IgM antibody to Japanese encephalitis virus was 0.62% (4/641), the positive rate for IgM antibody to dengue virus was 2.96% (19/641) and the positive rate for IgM antibody to West Nile virus was 1.72% (11/641). Six serum samples showed neutralization antibody to mosquito-borne flavivirus, the neutralization titers ranged from 1 ∶ 10 to 1 ∶ 40. Conclusion The antibody to mosquitio-borne flavivirus could be detected in the cases of fever with unknowen orgin in Xinjiang by ELISA or neutralization test.