GUO Yuan-yu, WU Wei-zhi, SHEN Li-fang, DONG Hua-li. Surveillance of drug resistance of Haemophilus influenzae in Hangzhou, Zhejiang, 2006-2011[J]. Disease Surveillance, 2012, 27(5): 349-352. DOI: 10.3784/j.issn.1003-9961.2012.5.006
Citation: GUO Yuan-yu, WU Wei-zhi, SHEN Li-fang, DONG Hua-li. Surveillance of drug resistance of Haemophilus influenzae in Hangzhou, Zhejiang, 2006-2011[J]. Disease Surveillance, 2012, 27(5): 349-352. DOI: 10.3784/j.issn.1003-9961.2012.5.006

Surveillance of drug resistance of Haemophilus influenzae in Hangzhou, Zhejiang, 2006-2011

  • Objective To understand the clinical distribution and drug resistance of Haemophilus influenzae in Xiaoshan district in Hangzhou and provide evidence for clinical antibiotic use. Methods The drug susceptibility of H. influenzae strains isolated in Zhejiang Xisoahn hospital from January 2006 to December 2011was tested by using ATB HAEMO strip, -lactamases was detected with Nitrocefin discs test, and the results were analyzed retrospectively by using WHONET 5.6 software. Results A total of 375 H. influenzae isolates were tested, the resistance rate was 66.1% to trimethoprim-sulfamethoxazole (TMP/SMZ), 33.8% to ampicillin, 10.2% to chloramphenicol, 13.8% to cefaclor and 14.7% to tetracycline. Amoxicillin/clavulanic acid, cefuroxime, cefotaxime, rifampicin and ofloxac in had good antibacterial activity on H. influenzae (the resistance rate 5.0%). The resistance rate to multi drugs of -lactamase positive strains was significantly higher than that of negative strains (P0.01). Conclusion TMP/SMZ is not suitable for the treatment of H. influenzae infection due to the high resistance rate. Ampicillin should be used with caution in empiric treatment. The resistance rate of H. influenzae to ampicillin is in decline, while the resistance rate to 2nd generation cephalosporin is in increase, it is important to use antibiotics rationally according to the drug susceptibility test results.
  • loading

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return