Drug resistance of 6158 smear positive tuberculosis patients in Sichuan

Objective To analyze the drug resistance in patients with pulmonary tuberculosis (TB) and understand the epidemiological characteristics of drug resistant tuberculosis in Sichuan province during 2011-2015. Methods Retrospective survey was conducted among all sputum smear positive pulmonary TB patients in 108 counties (districts) of 12 prefectures (municipality) and MDR-TB high-risk population by detecting their drug susceptibility to isoniazid, rifampicin, ofloxacin and kanamycin,comparative analyses of their drug resistance and epidemiological characteristics were conducted. Results A total of 6158 TB patients were surveyed, the overall drug resistance rate was 43.10%, the drug resistance rate was 32.00% in new TB patients and 53.97% in re-treated patients, there was significant difference (2=303, P0.01). The resistant rate to isoniazid was highest, followed by ofloxacin, rifampicin and kanamycin.MDR-TB patients accounted for 30.97% of drug resistant TB patients, XDR-TB patients accounted for 18.13% of MDR-TB patients. The drug resistant rate was 45.19% in males, higher than that in females (2=21.06, P0.01). The drug resistant rate was 45.77% in rural patients, higher than that in urban patients. The drug resistan rate in patients aged 30-60 was higher than that in other age groups. Conclusion The drug resistant rate of sputum smear positive TB patients and MDR-TB patients in Sichuan washigher than national level, and higher than that in the fifth epidemiological investigation in Sichuan during 2010. Male patients aged 45-60 years in rural areas were the key population in the prevention and control of drug resistance TB in Sichuan.