Distribution of serotypes and drug resistance of ESBLs-producing Salmonella in Wenzhou, Zhejiang

Objective To study the serotype distribution and drug resistance characteristics of ESBLs-producing Salmonella in Wenzhou, Zhejiang province, from 2013 to 2017 and provide evidence for the disease prevention, diagnosis and treatment in clinical practice.

Methods From January 2013 to December 2017, a total of 294 Salmonella strains were collected from our hospital and all the district centers for disease control and prevention in Wenzhou, and the serotypes of ESBLs-producing Salmonella strains were confirmed by E-test quantitative analysis. The drug sensitivity and epidemiological characteristics of the strains were analyzed.

Results The screening of 294 strains of Salmonellafound 68 (23.13%) ESBLs-producing strains, involving three serotypes and including 41(60.29%, 41/68) Salmonella typhimurium strains , 19(27.94%, 19/68) Salmonellaenteritis strains and 8(11.76%, 8/68) Salmonella derby strains . The cases were mainly children aged 3–5 years (61.76%, 42/68) and infants aged 0–2 years (17.65%, 12/68). The clinical samples were mainly intestinal samples, accounting for 69.12% (47/68), followed by blood samples, accounting for 30.88% (21/68). The resistant rate of ESBLs producingSalmonella was 41.18% to cefepime, 52.94% to compound sulfamethoxazole and 47.06% to tetracycline. No strains which were resistant to imipenem, ciprofloxacin and levofloxacin were found.

Conclusion The transmission of ESBLs-producing Salmonella was serious in Wenzhou, the major serotype was Salmonella typhimurium, which were mainly detected in infants. ESBLs-producing Salmonella has different resistance to antibiotics, especially the poor sensitivities to cefepime, compound sulfamethoxazole, tetracycline, etc. Multidrug resistance monitoring should be strengthened in clinical practice.