Gene polymorphism related with tuberculosis susceptibility in 364 Mongolian population

ObjectiveTo explore the relationship between NRAMP1, Sp110 gene polymorphism and susceptibility to tuberculosis (TB) in inner Mongolia population.

MethodsA case-control study was conducted, a total of 180 TB patients and 184 healthy controls were selected in inner Mongolia population. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) test was performed by using blood samples to detect the genotypes, and analyze the genotype frequency distribution in the case group and the control group. The relationship between genotype and environmental factors and TB susceptibility was analyzed with χ² test and logistic regression.

ResultsSingle factor χ² analysis indicated that except body mass index (BMI) the other factors had balanced distribution between two groups, the gene polymorphisms of NRAMP1rs17235409, NRAMP1rs17235416 and Sp110rs3948464 loci were associated with the susceptibility to TB, the susceptibilities of mutated genotype GA＋AA, TGTG/(－)＋(－)/(－), and CC to TB were 1.784, 4.745 and 3.061 times higher than those of non-mutated genotype GG, TGTG/TGTG, TT. People with BMI＜18.5, a risk factors for TB, had a 4.350 times higher risk for TB compared with those with BMI≥18.5.

ConclusionThe gene polymorphisms of NRAMP1rs17235409, NRAMP1rs17235416 and Sp110rs3948464 loci is associated with the susceptibility to TB in inner Mongolia population.