Shilin Xiao, Xueyang Jia, Xudong Nie, Tian Qin, Hongyu Ren. Antibiotic resistance of 101 Legionella strains[J]. Disease Surveillance, 2019, 34(10): 928-931. DOI: 10.3784/j.issn.1003-9961.2019.10.015
Citation: Shilin Xiao, Xueyang Jia, Xudong Nie, Tian Qin, Hongyu Ren. Antibiotic resistance of 101 Legionella strains[J]. Disease Surveillance, 2019, 34(10): 928-931. DOI: 10.3784/j.issn.1003-9961.2019.10.015

Antibiotic resistance of 101 Legionella strains

  • ObjectiveTo investigate the drug resistance of Legionella from different sources and serotypes/groups.
    MethodsAntibiotic susceptibility tests of Legionella to erythromycin, rifampicin, levofloxacin, sulbactam, azithromycin, moxifloxacin and cefuroxime were carried out by using 101 Legionella strains, including 67 environmental isolates, 16 clinical isolates and 18 international reference strains, in 17 serotypes.
    ResultsOnly three of the strains showed no antibiotic resistance. The other 98 strains were resistant to seven antibiotics at different degrees. The resistance rate was 69.31% to cefuroxime (n=70), 8.91% to azithromycin (n=9), 7.92% to moxifloxacin (n=8), 5.94% to rifampicin (n=6), 4.95% to sulbactam (n=5), 2.97% to erythromycin (n=3), and 0.99% to levofloxacin (n=1). Among the 17 serotypes, 13 serotypes were found to be resistant to cefuroxime, and 4 serotypes were multi-drug resistant (≥ 2 antibiotics). The serotype of simultaneous resistant to sulbactam and cefuroxime was LP4; the serotype of simultaneous resistant to cefuroxime and moxifloxacin was LP5; the serotype of simultaneous resistant to erythromycin, sulbactam and cefuroxime was LP9; and the serotype of simultaneous resistant to erythromycin, azithromycin, levofloxacin, moxifloxacin, rifampicin, sulbactam and cefuroxime was LP1. The remaining 9 serotypes were only resistant to cefuroxime. In addition, two non-L. pneumophila serotypes (L. oakridgensi) were only resistant to azithromycin. LP3, L. feeleii and L. bozemanii were sensitive to all antibiotics.
    ConclusionErythromycin, a first-line antibiotic for legionellosis, could still be used as the first choice in clinical treatment. In addition, quinolone antibiotic levofloxacin can also be used as an alternative in the treatment of legionellosis. Cefuroxime, which is the most resistant drug, should be avoided to use in the treatment of legionellosis.
  • loading

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return