ObjectiveTo investigative the antibiotic susceptibility of common Haemophilus in healthy population in Suizhou of Hubei province.
MethodsIn 2011 and 2016, the throat swabs of healthy population in Suizhou were collected for Haemophilus isolation and culture, slide agglutination test and fluorescence PCR were conducted to identify the serotype and genotype of Haemophilus. Disk diffusion method (K-B method) was used to detect the antibiotic susceptibility of Haemophilus in vitro.
ResultThe positive detection rates of Haemophilus, Hemophilus hemolyticus and Haemophilus parainfluenzae in 2011 and 2016 were 11.90%, 4.76%,2.86% and 14.76%, 13.81%, 3.33%, respectively. The sensitivity rates of Haemophilus to ampicillin, cefaclor, cefixime, azithromycin, amoxicillin/clavulanic acid, ciprofloxacin and meropenem were 35.71%, 57.14%, 83.93%, 83.93%, 87.50%, 96.43% and 96.43% respectively; the sensitivity rates of H. hemolyticus to these antibiotics were 41.03%, 56.41%, 94.87%, 94.87%, 76.92%, 97.44% and 92.31% respectively and the sensitivity rates of H. parainfluenzae to these antibiotics were 53.85%, 76.92%, 84.62%, 100%, 76.92%, 53.85% and 76.92%, respectively. The sensitivity rates of Haemophilus and H. parainfluenzae to meropenem (P＝0.015) and ciprofloxacin (P＜0.001) showed significant differences. However, the sensitivity rates to other five antibiotics exhibited no significant differences (P＞0.05). Compared with the Haemophilus isolated in 2011, the isolates of 2016 showed an obvious decrease in sensitivity to ampicillin (P＝0.025), cefaclor (P＝0.044), cefixime (P＝0.027) and azithromycin (P＝0.003). The sensitivity to amoxicillin/clavulanic acid (P＝0.045) and azithromycin (P＝0.013) of H. hemolyticus showed significant decreases. The sensitivity rates of H. parainfluenzae to the 7 antibiotics showed no significant differences.
ConclusionThe sensitivity of Haemophilus varied with its species. Over time, the sensitivity of Haemophilus showed obvious decreases to some antibiotics.
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