Comparisons of transcriptome between gastric MALT isolates and gastric ulcer isolates of Helicobacter pylori

ObjectiveHelicobacter pylori is the main cause of gastric mucosa-associated lymphoid tissue lymphoma (MALT lymphoma). This study aimed to characterize the transcriptome characteristics of gastric MALT lymphoma isolates in comparison with gastritis isolate of H. pylori.

MethodsThe transcriptome of two gastric MALT lymphoma isolates and gastritis isolate (26695) of H. pylori were compared.

ResultsThe transcriptome of the two MALT lymphoma isolates were very similar, in contrast, there was great difference between the MALT lymphoma isolates and gastritis isolate (26695). GO enrichment analysis showed that the top five enriched items were catalytic activity, binding, metabolic process, cellular process, and single-organism process. Pathway enrichment showed that the differentially transcribed genes were mainly with functions in amino sugar and nucleotide sugar metabolism, porphyrin and chlorophyll metabolism, and glyoxylate and dicarboxylate metabolism.

ConclusionH. pylori gastric MALT lymphoma isolates may play an important role in the formation of gastric MALT lymphoma by metabolic regulation of bacterial growth and infection of host.