ObjectiveTo analyze the epidemiological and clinical characteristics, and pathogen spectrum changes in adult patients visiting enteric disease clinics due to acute bacterial diarrhea in in Beijing from 2015 to 2018.
MethodsFrom January 2015 to December 2018, the clinical and epidemiological data of the acute diarrheal cases and their stool samples were collected in Beijing. The samples were tested for Vibrio cholerae, Shigella, Salmonella and other intestinal bacteria. Univariate logistic regression analysis was conducted to analyze the epidemiological and clinical factors for the positivity of bacterial infection, and multivariate logistic regression was used to adjust confounding factors. Descriptive analysis was used to identify the pathogen spectrum changes.
ResultsFrom 2015 to 2018, a total of 13 126 samples were collected, of which 2 689 were bacteria-positive (20.49%). The annual positive detection peaked from July through September. The related epidemiological factors of intestinal bacterial infection included age, residence and season. The differences in positive rate of bacterial infection among years were significant. Fever (≥38.5 ℃), abdominal pain, nausea, vomiting were the clinical symptoms of intestinal bacterial infection. Diarrhea of 6–10 times per day was associated with higher positive detection rate compared with 3–5 times per day. Cases diagnosed as infectious diarrhea had higher positive detection rate than the ones diagnosed as non-infectious diarrhea. From 2015 to 2018, the major intestinal bacteria detected were Escherichia coli, Salmonella and V. parahaemolyticus, but the distribution of pathogen spectrum varied with years.
ConclusionFrom 2015 to 2018, the major intestinal bacteria detected in adults in Beijing were E. coli, Salmonella and V. parahaemolyticus. Specific prevention and control measures shall be strengthened for intestinal bacterial diarrhea with certain epidemiological and clinical characteristics.
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