Mortality and years of life lost caused by major kidney diseases in Jiangsu province, 2010–2018

ObjectiveTo understand the mortality and years of life lost (YLL) of major kidney diseases as well as related trends in Jiangsu province between 2010 and 2018, and provide scientific basis for the prevention and control of major kidney diseases in the future.

MethodsThe death case data between January 1, 2010, and December 31, 2018 and the gender and age specific population data between 2009 and 2018 in Jiangsu were collected from National Death Cause Surveillance System and local public security department respectively. The mortality rate, YLL rate, average YLL, age-standardized mortality rate and its annual percentage change (APC) were calculated by using SPSS (Version18.0) and Joinpoint (Version4.6) to evaluate the level of the disease burden.

ResultsBetween 2010 and 2018, the death numbers caused by major kidney diseases in total population, males and females in Jiangsu were 41 819, 23 969 and 17 850, respectively, the mortality rates in 2010 and 2018 were 6.17/100 000 and 6.96/100 000, respectively, the age-standardized mortality rate significantly decreased, the APC (95%CI) was −2.75% (−3.72% – −1.78%). The YLLs caused by major kidney diseases in total population, males and females were 966 493.40, 575 115.70 and 391 377.70 years, respectively, the related average YLLs were 23.11years/person, 23.99years/person and 21.97 years/person, respectively; the YLL rates in 2010 and 2018 were 1.53 years per 1000 persons and 1.55 years per 1 000 persons, respectively, the age-standardized YLL rate significantly decreased, the APC (95%CI) was −2.59% (−3.53% – −1.64%). The age-specific mortality rates and age-specific YLL rates of major kidney diseases were all at low levels before the age of 30 years and increased slowly after the age of 30 years, and increased rapidly after the age of 60 years. The age-standardized mortality rate and age-standardized YLL rate of kidney cancer significantly increased, but those of both glomerular disease and tubulointerstitial disease showed no significant changes, and those of renal failure decreased significantly.

ConclusionBoth the overall death burden and premature death burden of four major kidney diseases in Jiangsu decreased significantly between 2010 and 2018. Both the death burden and early death burden in males were more severe than those in females. Both the death burden and premature death burden of kidney cancer increased, suggesting that more attention need to be paid to its prevention and control in the future.