Investigation on tetanus antibody in healthy people in Jinjiang, Fujian province, 2019

ObjectiveTo determine tetanus antibody (TAB) levels of healthy population in Jinjiang city in 2019.

MethodsWe collected the sera sample of healthy population at different age in 2019 by stratified random sampling, and detected TAB levels by enzyme-linked immunosorbent assay.

ResultsThe overall positive rate of TAB among 775 subjects was 39.2% (304/775), and the positive rate of TAB in each age group was 71.9% (87/121, aged 8–20 years), 53.6% (82/153, aged 21–30 years), 39.3%(57/145, aged 31–40 years), 25.2% (38/151, aged 41–50 years), 16.2%(17/105, aged 51–60 years), and 23.0% (23/100, over 61 years old), respectively. The positive rate of TAB was 70.7% (164/232) in subjects who had been immunized with tetanus toxoid-containing vaccine (TTCV) in the past years, while 25.8% (140/543) in subjects without or with uncertain TTCV immunization history. For the TAB negative population, there was statistically significant difference in age group distribution between tetanus high-risk industries and tetanus low-risk industries ( χ²=62.185, P<0.000). People aged 41–50 years in tetanus high-risk industries accounted for 46.79%.

ConclusionThe overall positive rate of TAB in healthy population decreased significantly with age. More attentions should be paid to enhance TTCV immunization.