Early diagnostic detection of AIDS in HIV-exposed infants in Xinjiang, 2015–2019

ObjectiveTo understand the performance of early diagnostic detection of AIDS in HIV-exposed infants in Xinjiang from January 2015 to September 2019 and provide evidence for increasing the early diagnosis rate in HIV-exposed children in Xinjiang and further reducing mother-to-child transmission of HIV.

MethodsThe sample data of HIV exposed infants born from January 2015 to September 2019, which were obtained from AIDS early diagnosis laboratory in Xinjiang, were analyzed, and software SPSS was used to compare the differences in early diagnosis rate, sample collection time and positive test rate in different years.

ResultsFrom January 2015 to September 2019, a total of 1 636 exposed infants born by HIV-infected mothers were reported in Xinjiang, in whom 1 272 received at least one early diagnostic detection (77.8%), and 995 received two early diagnostic detections (60.8%), and the rate of two early diagnostic detections increased year by year ( χ²=119.09, P<0.001). The proportion of HIV-exposed infants with the first sample collected within 42 d after birth was 18.8%, the median was 48 d (range: 0–301 d); the proportion of HIV-exposed infants with the second sample collected within 90 days after birth was 13.4%, the median was 100 d (range: 66–564 d). Among the 995 HIV-exposed infants who received two early diagnostic detections, 38 had positive results (3.8%).

ConclusionThe rate of early diagnostic detection of AIDS in HIV-exposed infants in Xinjiang increased with year, and the early diagnostic detection network has become more perfect. The rate of two early diagnostic detections in HIV-exposed infants and the timeliness of sample collection still need to be improved.