Drug resistance of Helicobacter pylori in Wenling, Zhejiang, 2009–2019

  Objective  To analyze the drug resistance of Helicobacter pylori (H.pylori)in different age groups in Wenling, Zhejiang province, from 2009 to 2019, and provide reference for individualized treatment of H. pylori infection.

  Methods  The gastric mucosal samples of patients undergoing gastroscopy from 2009 to 2019 were collected, H. pylori strains were isolated, and the strains’ drug resistances to amoxicillin, levofloxacin, clarithromycin and metronidazole were detected. The antibiotic resistance rates and trends of H. pylori in different age groups divided by 10 years old were analyzed.

  Results  A total of 95 448 gastric mucosal samples from patients undergoing gastroscopy were collected, in which 28 774 H. pylori strains were isolated. The average resistance rates of H. pylori to amoxicillin, clarithromycin, levofloxacin, and metronidazole in Wenling were 0.37%, 23.52%, 30.62% and 3.61%, respectively. The resistance rates to clarithromycin and levofloxacin increased with age. The resistance rate to metronidazole, clarithromycin and levofloxacin in people aged <20 years increased faster compared with other age groups.

  Conclusion  The antibiotic resistance of H. pylori in Wenling was relatively serious, and the resistance rates in young and old age groups increased significantly, indicating that special attention should be paid to it.