Objective To understand the infection status of pathogenic bacteria and drug resistance characteristics in diarrhea patients in Miyun district, Beijing, and provide evidence for the prevention and treatment of infectious diarrhea.
Methods The stool samples were collected from two sentinel hospitals in Miyun (Miyun District Hospital and Miyun Traditional Chinese Medicine Hospital) from 2014 to 2019. Pathogenic bacteria were identified by culture and isolation and drug resistances were analyzed. Diarrhea related viruses were also detected by real-time PCR.
Results From 2014 to 2019, a total of 1 870 stool samples were collected. And 267 strains of bacteria (84 Salmonella strains, 52 Vibrio strains, 111 Escherichia coli strains, 10 Aeromonas strains, 8 Campylobacter strains, 2 Shigella strains) were isolated. And 314 samples were positive with viruses (204 with norovirus GⅡ, 28 with norovirus GⅠ, 61 with rotavirus, 17 with adenovirus, 4 with zaravirus). The highest positive rate was in age group ≤14 years (43.95%). The highest annual detection rate of diarrhea pathogens was in the third quarter, with an average positive rate of 40.26% in six years. The annual detection rate of diarrhea related viruses were higher in the first and fourth quarters, with an average positive rate of 18.86% and 23.63% respectively in six years. The drug resistance rates of Salmonella and diarrheagenic E. coli were 84.52% and 87.39% respectively. 36.90% of Salmonella strains and 36.94% of diarrheagenic E. coli strains were multidrug resistant.
Conclusion In Miyun district, the composition of pathogens causing diarrhea tends to be diversified. Multidrug resistance of bacteria is serious. It is necessary to strengthen the pathogen surveillance, promote collaborations of multidisciplinary to response together, strengthen the management and rational use of drugs, and take effective measures to prevent and control the occurrence of drug resistance.
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