Progress in research of extra-intestinal infection of rotavirus

Rotavirus is the most important pathogen of intestinal infections in children, often causing gastrointestinal symptoms. Rotavirus infects the brain, liver, lungs, heart, kidneys and other organs, causing a series of systemic diseases, through viremia and possible respiratory transmission. However, the mechanism of extra-intestinal infection is not yet clear, further study is still needed. This paper summarizes the pathogenesis, laboratory diagnosis and clinical manifestations of central nervous system damage, liver damage, type 1 diabetes, respiratory system damage and heart damage caused by extra intestinal infection of rotavirus to provide help for the exploration of the mechanism of extra-intestinal infection of rotavirus.