Objective To analyze the clinical and epidemiological characteristics of enteroviruse-D68 (EV-D68) infection in patients with acute respiratory tract infection in Beijing from 2018 to 2019.
Methods The epidemiological data and clinical samples were collected from respiratory infection patients in 35 sentinel hospitals in respiratory pathogen surveillance in Beijing. All the samples were subjected to EV and EV-D68 detections by real-time PCR. The VP1 gene sequences of EV-D68 positive samples were analyzed.
Results Of 15 645 clinical samples from respiratory infection cases, 467 (2.98%) were EV positive and 22 (0.14%) were EV-D68 positive. Of the 22 EV-D68 infection cases, 11 were aged ＜18 years, 7 were aged 18−60 years and 4 were aged ＞60 years. Eight cases were diagnosed with upper respiratory tract infection and 14 cases were diagnosed with pneumonia, including two severe pneumonia cases. The main symptoms for EV-D68 infection cases were fever (18/22, 81.8%) and cough (15/22, 68.2%). Seven cases were detected in summer (June-August), 11 cases in autumn (September-November), 3 cases in winter (December-February) and 1 case in spring (March-May). Fourteen strains of 22 EV-D68 belonged to subclade B3 and D3, in which 8 strains belonged to subclade B3 and 1 strain blonged to subclade D3 in 2018, while 5 strains in 2019 belonged to subclade D3.
Conclusion Respiratory tract infection caused by EV-D68 persisted in Beijing, mainly in summer and autumn. Subclade B3 and new subcalde D3 were the main pathogen subtypes.
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