Progress in research of molecular typing of Leptospira in China

With the development of molecular biology, genomics and bioinformatics, the molecular epidemiology of Leptospira has been further studied. New molecular typing methods and the sequencing of a large number of Leptospira genomes have enabled researchers to gain a new understanding of Leptospira. Based on the molecular classification methods of Leptospira applied at home and abroad in recent years, this paper summarizes the 16S rRNA genotyping, pulsed field gel electrophoresis, site sequence classification, site variable number tandem repeat sequence classification and whole genome sequencing to help the finding of new type strains of Leptospira, and revealing the host and regional transmission relationship among different strains. This review can provide reference for the application of molecular typing methods and the prevention and control of leptospirosis in the future.