Serological analysis on antibody levels to measles, rubella and mumps in healthy people in different age groups in Liaoning, 2020

  Objective   To investigate the IgG antibody levels to measles, rubella and mumps in healthy people in different age groups ten years after the implementation of the Expanded Immunization Program in Liaoning province, and provide Evidence for the timely detection of immune vulnerable groups and targeted immunization measures.

  Methods  A total of 498 healthy people’s blood samples were collected from monitoring sites in 6 counties of 3 cities in Liaoning by random sampling method. Serum IgG antibodies were detected by enzyme-linked immunosorbent assay for measles, rubella and mumps, and the positive rate and geometric mean concentration (GMC) of antibodies were analyzed.

  Results  The positive rate of measles antibody was 94.78%, and the GMC was 851.10 mIU/mL; the positive rate of rubella antibody was 87.15%, and the GMC was 40.90 IU/mL; the positive rate of mumps antibody was 90.16%, and the GMC was 330.93 U/mL. The differences in positive rates and GMC levels of measles, rubella and mumps were significant among different areas (P<0.01). The differences in GMC level of measles, the positive rate of rubella and mumps IgG antibody and GMC level were significant among different age groups (P<0.01), but there was no significant difference in the positive rate of measles IgG antibody (P>0.05), and there were no gender specific statistical differences in the positive rate of measles, rubella and mumps IgG antibody and GMC levels (P>0.05).

  Conclusion  The levels of IgG antibody to measles and mumps were high in Liaoning, but the level of IgG antibody to rubella was low. Antibody levels in children and adolescents decreased over time after vaccination, and so the targeted immunization strategies should be strengthened in adolescents.