Analysis on time trends of breast cancer death and life lost in women in Huzhou, 2012−2021

  Objective  To analyze the distribution characteristics and life lost time trend of breast cancer in women in Huzhou, Zhejiang province, from 2012 to 2021, and provide evidence for the prevention and treatment of breast cancer in women.

  Methods  The data of breast cancer death surveillance in women in Huzhou from 2012 to 2021 were collected from the surveillance information management system of Zhejiang province, the crude mortality rate, standardized mortality rate, potential life lost year (PYLL) and potential work loss year (WPYLL) of breast cancer were calculated. The annual percentage (APC) was used to analyze the time trend of breast cancer death in women.

  Results  The crude death rate of breast cancer in women in Huzhou increased from 5.43/100 000 in 2012 to 7.10/100 000 in 2021, and APC was 3.98%, showing an upward trend (P<0.05); the standardized mortality increased from 3.98/100 000 to 5.19/100 000, and the APC was 1.82%. The earliest death occurred at age of 18 years, and the mortality increased gradually from age of 30 years, and the sub-peak (13.08/100000) occurred in age group 55−59 years, and the peak (23.38/100000) occurred in age group 80−84 years. The mortality in age group of 70−74 years showed an upward trend with time (APC=7.57%, P=0.016). The PYLL caused by breast cancer death was 9985 years, and the PYLL rate increased from 0.66‰ in 2012 to 0.77‰ in 2021. The WPYLL was 6267 person years, and the WPYLL rate increased from 0.43‰ to 0.44‰ with no obvious change trend. The rates of PYLL and WPYLL of female breast cancer increased first and then decreased with age, reaching peaks of 1.90‰ and 1.30‰, respectively, at age of 50−54 years,.

  Conclusion  During 2012−2021 the crude mortality rate of breast cancer in women in Huzhou was in increase. The earliest death of breast cancer occurred at age of 18 years. The high-risk group was women aged 50–54 years. There was no significant differences in the PYLL and WPYLL caused by female breast cancer. It is necessary to strengthen the health education about breast cancer and promote healthy lifestyle in young women, improve the early detection, early treatment and early blocking of breast cancer in middle-aged women to reduce precancerous lesions and the incidence and mortality of breast cancer.