In September 2022, a total of 67 infectious diseases were reported globally, affecting 235 countries and regions. Except for influenza, the top five infectious diseases affecting greatest number of countries and regions were COVID-19 (235), monkeypox (106), dengue fever (32), measles (25) and cholera (15). The top five infectious diseases with highest case fatality rates were Rift Valley fever (69.2%), Marburg virus disease (66.7%), Ebola virus disease (63.9%), Lassa fever (18.5%) and West Nile fever (6.3%). The top five infectious diseases with greatest number of deaths were COVID-19, malaria, dengue fever, measles and cholera. The prevalent infectious diseases in Asia were COVID-19, cholera and dengue fever, the prevalent infectious diseases in Africa were COVID-19, Ebola virus disease, cholera, plague, yellow fever, Lassa fever, malaria and monkeypox, the prevalent infectious diseases in America were COVID-19, dengue fever, chikungunya fever, Zika virus disease and monkeypox, the prevalent infectious disease in Europe were COVID-19, monkeypox and West Nile fever.