Objective To investigate the association between triglyceridemic waist and risk for prediabetes and diabetes in people in different body mass index (BMI) groups and provide evidence to improve the obesity management.
Methods Based on the data from early screening and intervention for population at high risk for cardiovascular diseas in Changning and Baoshan districts of Shanghai from 2016 to 2020, questionnaire survey, physical examinations and laboratory tests were conducted to collect the information about the sociodemographic characteristics, including lifestyle and disease history, anthropometric measurement, including body height and weight, and blood glucose or blood lipid indicators of this population. Multivariate logistic regression analysis was used to analyze the association between triglyceridemic waist phenotype and risk for prediabetes and diabetes in people in different BMI groups .
Results A total of 24 318 middle-aged and old participants were finally included in the study, in whom 11 536 were with normal triglycerides and waist circumference, 5 650 were with only abdominal obesity, 3 745 were with only high triglyceride, and 3387 were with high triglyceride and abdominal obesity (HTWC). HTWC was significantly associated with the higher risk for prediabetes and diabetes regardless of BMI level. Compare with the controls with normal triglycerides and waist circumference in each BMI groups, the odds ratios for prediabetes and diabetes in people were 1.46 (95%CI: 1.15–1.86) and 3.23 (95%CI: 2.44–4.25) in people with HTWC in normal BMI group, 1.55 (95%CI: 1.34–1.80) and 3.24 (95%CI: 2.67–3.96) in overweight people with HTWC, 1.43 (95%CI: 0.96–2.18) and 2.23 (95%CI: 1.32–3.95) in obese people with HTWC.
Conclusion The HTWC phenotype can be used to help identify high-risk groups of diabetes, even in people with normal BMI. Targeted interventions should be conducted to further reduce the risk for cardiometabolic diseases.
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