Measles antibody level and related factors in healthy population in Hunan, 2020−2021

  Objective   To understand the measles antibody level and related factors in healthy population in Hunan province.

  Methods  A total of 3290 healthy persons were selected from 6 counties in Hunan during 2020−2021 through multistage stratified random sampling. Blood samples were collected from them for the detection of measles IgG antibody with enzyme-linked immunosorbent assay. The positive rate and geometric mean concentration (GMC) of measles IgG antibody were calculated and analyzed. The influencing factors of measles IgG antibody positive rate were identified by using the multivariate logistic regression analysis. The influencing factors of measles IgG antibody GMC were identified by using the multiple linear regression analysis.

  Results  The positive rate of measles IgG antibody was 75.08% and the measles IgG antibody GMC was 426.67 mIU/mL in healthy population in Hunan. The differences in the positive rate and GMC were significant among different areas, age groups, measles containing vaccine (MCV) dose groups, and peoples with different intervals from last MCV dose (P<0.05). Multivariate logistic regression showed that age, and MCV dose were factors for positive rate of measles IgG antibody. Multiple linear regression analysis showed that the interval from last MCV dose was factor for measles IgG antibody GMC in people with MCV vaccination.

  Conclusion  The positive rate and GMC of measles IgG antibody were generally low in healthy population in Hunan during 2020−2021. We should maintain high coverage of timely 2 doses of MCV immunization in age-eligible children. Effective measles supplementary immunization activity should be carried out in key places and populations if necessary.