Pathogenetic characteristics of the first local case of severe fever with thrombocytopenia syndrome in Beijing

  Objective  To investigate the pathogenetic characteristics of the first local case of severe fever with thrombocytopenia syndrome (SFTS) in Beijing.

  Methods  Virus isolation from patient samples and full-genome sequencing were performed, followed by homology comparison and phylogenetic analysis with different genotypes of SFTS virus. Recombination and amino acid mutation site analyses were also conducted.

  Results  The virus was isolated from the patient's blood sample and named as BJ001-2021. The L and M segments of the isolated virus were most closely related to the 17-China_Henan-72 strain from Henan, while the S segment was most closely related to the SD2013-094 strain from Shandong. Phylogenetic tree indicated that BJ001-2021 belongs to genotype B, along with HB29 and SD24, and no gene recombination occurred, however, some amino acid mutation sites were identified.

  Conclusion  The first local case of SFTS in Beijing was caused by SFTS virus genotype B, and no gene recombination or reassortment occurred.