Retrospective analysis of blood transmitted diseases in voluntary blood donors in Wenzhou, 2006 - 2008

Objective This study analyzed the results of blood transmitted disease tests for voluntary blood donors in Wenzhou from 2006 through 2008, providing evidence for blood management in this region. Methods The results of blood transmitted disease tests for voluntary blood donors in Wenzhou from January 1,2006 to June 30,2008 were collected and retrospectively analyzed. Results A large proportion of the donors were found ineligible due to detectable blood transmitted diseases: 4.77% were HBsAg positive (4527/94 830),11.50% had abnormal ALT level (10 442/90 786), 0.02% were HIV positive (15/81 199), 0.30% were syphilis-antibody positive (243/81 199), and 0.45% were anti-HCV positive (363/81 199). Among the anti-HCV positives, males accounted for 0.51% of the corresponding surveyed population (257/50 229), higher than females that accounted for 0.34% (106/30 970), which was of statistical significance (2= 12.351, P0.001). No significant difference was found in the seroprevalence between the 18- to 35-year-old group and the 36- to 55-year-old group, whereas the anti-HCV seroprevalence was significantly different between the areas where voluntary blood donors exceeded a thousand (2 = 22.958, P=0.011). The highest anti-HCV seroprevalence was in Henan province (0.81%), remarkably higher than that in Wenzhou (2= 13.594, P0.001). Conclusion A large number of ineligible blood donors were found in Wenzhou from 2006 to 2008, with an HBsAg seroprevalence of 4.77%, which was lower than the national census value; a prevalence of abnormal ALT of 11.50%; and an anti-HCV prevalence of 0.45%, which was higher in males than in females. The anti-HCV seroprevalence among blood donors from Henan was higher than those who were Wenzhou natives. This study was funded by the subject sponsored by Wenzhou Municipal Health Bureau (No.2009B072)