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Volume 40 Issue 2
Feb.  2025
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Shao Jianchao, Zhi Qian, Feng Shurong, Yang Bo, Yan Xinyue, Wang Yong, Liu Shudan. Epidemiological characteristics of pertussis from 2014 to 2023 and pertussis antibody level in children aged 1−<5 years in Shapingba district of Chongqing[J]. Disease Surveillance, 2025, 40(2): 171-175. DOI: 10.3784/jbjc.202405280308
Citation: Shao Jianchao, Zhi Qian, Feng Shurong, Yang Bo, Yan Xinyue, Wang Yong, Liu Shudan. Epidemiological characteristics of pertussis from 2014 to 2023 and pertussis antibody level in children aged 1−<5 years in Shapingba district of Chongqing[J]. Disease Surveillance, 2025, 40(2): 171-175. DOI: 10.3784/jbjc.202405280308
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Epidemiological characteristics of pertussis from 2014 to 2023 and pertussis antibody level in children aged 1−<5 years in Shapingba district of Chongqing

  • 1.

    Shapingba District Center for Disease Control and Prevention, Chongqing 400038, China

  • 2.

    Chongqing Medical University, Chongqing 400016, China

Funds: This study was supported by the Chongqing Shapingba District Technology Innovation Project (No. 2024084)
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  • Received Date: May 27, 2024
  • Available Online: October 28, 2024
  • Published Date: October 28, 2024
    Graphical Abstract
    • Abstract
  • Objective 

    To describe the epidemiological characteristics of pertussis and understand the antibody level in 1−<5 years old population in Shapingba district of Chongqing from 2014 to 2023.

    Methods 

    A descriptive epidemiological analysis was conducted on the incidence data of pertussis in Shapingba from 2014 to 2023, which were collected from China Disease Control and Prevention Information System. Blood samples collected from healthy children aged 1−<5 years in Shapingba from September to November, 2022 were used for pertussis antibody level detection with enzyme-linked immunosorbent assay.

    Results 

    From 2014 to 2023, a total of 559 cases of pertussis were reported in Shapingba, with an average annual incidence rate of 4.48/100 000. The pertussis cases were distributed in different age groups, i.e. 326 cases in age group ＜1 year (427.06/100 000), 113 cases in age group 1− years (31.49/100 000), 107 cases in age group 5− years ( 17.55/100 000), and 13 cases in age group ≥10 years ( 0.10/100 000). The study found that 64 cases (13.82%) received no dose of diphtheria, tetanus and pertussis (DTP) vaccine at age ≥3 months, 88 cases (20.85%) received less than two doses of DTP vaccine at age ≥4 months, 76 cases (20.77%) received less than three doses of DTP vaccine at age ≥5 months, and 3 cases (1.78%) received less than four doses of DTP vaccine at age ≥18 months. The positive rate of pertussis IgG was 45.83% in age group 1 year, 37.78% in age group 2 years, 13.64% in age group 3 years, and 7.55% in age group 4 years (χ2=27.798, P＜0.01), with corresponding geometric mean concentrations of 71.80, 42.09, 32.71, and 19.23 IU/mL, respectively (F=5.530, P=0.001).

    Conclusion 

    Over the past decade, the relatively high and increased incidence of pertussis was observed in Shapingba. The high incidence of pertussis was observed in infants, especially in those receiving no DTP vaccine or receiving less than 3 doses. In children aged 1−<5 years, the level of pertussis antibody significantly decreased with age. It is necessary to strengthen the timely and full-series pertussis vaccination for age-eligible children and improve the childhood pertussis immunization strategy.

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    • References (17)
  • [1]
    World Health Organization. Pertussis vaccines: WHO position paper - August 2015[J]. Weekly Epidemiological Record, 2015, 90(35): 433−460.
    [2]
    World Health Organization. Pertussis reported cases and incidence[EB/OL]. (2023−06−26) [2024−05−20]. https://immunizationdata.who.int/pages/incidence/PERTUSSIS.html?code=Global&YEAR=.
    [3]
    World Health Organization. Diphtheria tetanus toxoid and pertussis (DTP) vaccination coverage[EB/OL]. (2023−06−26)[2024−05−20]. https://immunizationdata.who.int/pages/coverage/DTP.html?code=Global&ANTIGEN=DTPCV3&YEAR=.
    [4]
    张梦, 吴丹, 李艺星, 等. 全球百日咳防控面临的挑战[J]. 中华流行病学杂志,2023,44(3):491−497. DOI: 10.3760/cma.j.cn112338−20220825−00737.

    Zhang M, Wu D, Li YX, et al. Challenges to global pertussis prevention and control[J]. Chin J Epidemiol, 2023, 44(3): 491−497. DOI: 10.3760/cma.j.cn112338−20220825−00737.
    [5]
    张倩, 吴丹, 郑徽, 等. 中国2022年百日咳流行病学特征[J]. 中国疫苗和免疫,2024,30(1):34−38. DOI: 10.19914/j.CJVI.2024007.

    Zhang Q, Wu D, Zheng H, et al. Epidemiological characteristics of pertussis in China, 2022[J]. Chin J Vacc Immun, 2024, 30(1): 34−38. DOI: 10.19914/j.CJVI.2024007.
    [6]
    中华人民共和国卫生部. 百日咳诊断标准WS 274-2007[S]. 北京: 人民卫生出版社, 2007.

    Ministry of Health of the People's Republic of China. Diagnostic Standard for Pertussis WS 274-2007 [S].Beijing:People’s Medical Publishing House, 2007.
    [7]
    刘洋, 游贤路, 韩真明. 重庆市百日咳流行病学特征及影响因素分析[J]. 现代预防医学,2021,48(8):1372−1374,1394.

    Liu Y, You XL, Han ZM. Epidemiological characteristics of pertussis and influencing factors in Chongqing[J]. Mod Prev Med, 2021, 48(8): 1372−1374,1394.
    [8]
    张恺, 漆琪, 刘家洁, 等. 2014-2022年四川省百日咳流行病学特征[J]. 中国疫苗和免疫,2023,29(4):407−411. DOI: 10.19914/j.CJVI.2023070.

    Zhang K, Qi Q, Liu JJ, et al. Epidemiological characteristics of pertussis in Sichuan province, 2014-2022[J]. Chin J Vacc Immun, 2023, 29(4): 407−411. DOI: 10.19914/j.CJVI.2023070.
    [9]
    穆秋玥, 蒋凤. 2017-2019年贵州省百日咳流行病学特征[J]. 中国疫苗和免疫,2021,27(1):70−73. DOI: 10.19914/j.CJVI.2021005.

    Mu QY, Jiang F. Epidemiological characteristics of pertussis in Guizhou province, 2017-2019[J]. Chin J Vacc Immun, 2021, 27(1): 70−73. DOI: 10.19914/j.CJVI.2021005.
    [10]
    Yao N, Zeng Q, Wang Q. Seroepidemiology of diphtheria and pertussis in Chongqing, China: serology-based evidence of Bordetella pertussis infection[J]. Public Health, 2018, 156: 60−66. DOI: 10.1016/j.puhe.2017.12.009.
    [11]
    Hewlett EL, Edwards KM. Clinical practice. Pertussis-not just for kids[J]. N Engl J Med, 2005, 352(12): 1215−1222. DOI: 10.1056/NEJMcp041025.
    [12]
    Radke S, Petousis-Harris H, Watson D, et al. Age-specific effectiveness following each dose of acellular pertussis vaccine among infants and children in New Zealand[J]. Vaccine, 2017, 35(1): 177−183. DOI: 10.1016/j.vaccine.2016.11.004.
    [13]
    Sheridan S, McIntyre P, Liu B, et al. Pertussis burden and acellular pertussis vaccine effectiveness in high risk children[J]. Vaccine, 2022, 40(9): 1376−1382. DOI: 10.1016/j.vaccine.2021.10.013.
    [14]
    刘艳芹, 王莉, 于华凤, 等. 济南地区产妇与其新生儿百日咳抗体水平调查[J]. 临床儿科杂志,2020,38(10):726−729. DOI:10.3969/j.issn.1000−3606.2020.10.002.

    Liu YQ, Wang L, Yu HF, et al. The level of antibodies to Bordetella pertussis among pregnant women and their newborns in Jinan area[J]. J Clin Pediatr, 2020, 38(10): 726−729. DOI: 10.3969/j.issn.1000−3606.2020.10.002.
    [15]
    李驰, 郭九叶, 关莉, 等. 北京市三家妇幼保健院产妇及脐带血百日咳抗体水平调查[J]. 中华新生儿科杂志,2019,34(5):338−342. DOI:10.3760/cma.j.issn.2096−2932.2019.05.004.

    Li C, Guo JY, Guan L, et al. Pertussis antibody titers in pregnant women′s venous blood and cord blood-a survey from three women and children′s hospitals in Beijing[J]. Chin J Neonatol, 2019, 34(5): 338−342. DOI: 10.3760/cma.j.issn.2096−2932.2019.05.004.
    [16]
    Schwartz KL, Kwong JC, Deeks SL, et al. Effectiveness of pertussis vaccination and duration of immunity[J]. CMAJ, 2016, 188(16): E399−E406. DOI: 10.1503/cmaj.160193.
    [17]
    中华预防医学会, 中华预防医学会疫苗与免疫分会. 中国百日咳行动计划专家共识[J]. 中国公共卫生,2021,37(6):905−914. DOI: 10.11847/zgggws1134552.

    Vaccine and Immunology Branch of the Chinese Preventive Medicine Association, Chinese Preventive Medicine Association. Expert consensus on the China Pertussis Initiative[J]. Chin J Public Health, 2021, 37(6): 905−914. DOI: 10.11847/zgggws1134552.
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