Abstract: Objective To understand the incidence, epidemiological characteristics of infectious diarrhea and changes in the pathogens from 2012 to 2016 in Jiangmen, Guangdong province and provide evidence for developing prevention and control strategies. Methods The incidence data of infectious diarrhea in Jiangmen were collected from China Information System for Disease Control for statistical analysis. The stool samples of infectious diarrhea cases were collected from 2 sentinel hospitals for Vibrio cholerae, Shigella, rotavirus and norovirus detections.Results A total of 54 456 of other infectious diarrheal disease cases were reported in Jiangmen during this period, the cumulative incidence was 1.22%. No significant difference in the incidence between men and women was found. Most cases were 5 years old children outside child care settings. The incidence peak was during autumn-winter. Eighteen outbreaks caused by norovirus were reported. A total of 2 274 stool samples were detected, no Vibrio cholera and Shigella positive samples were detected, and the virus detection rate was 30.78%.Conclusion Other infectious diarrheal diseases mainly occurred in 5 years old children outside child care settings in Jiangmen during 2012-2016. The incidence was high during autumn-winter, and the case number reported in Kaiping was highest. Outbreak survey and etiological surveillance in sentinel hospitals indicated that norovirus was the predominant pathogen. It is necessary to take comprehensive and effective measures to prevent and control other infectious diarrheal diseases.