王春荣, 关恒云, 杨国樑, 赵红, 吕燕, 刘岚铮. 2010-2013年济南地区肠道病毒71型感染手足口病流行病学分析[J]. 疾病监测, 2015, 30(3): 194-197. DOI: 10.3784/j.issn.1003-9961.2015.03.008
引用本文: 王春荣, 关恒云, 杨国樑, 赵红, 吕燕, 刘岚铮. 2010-2013年济南地区肠道病毒71型感染手足口病流行病学分析[J]. 疾病监测, 2015, 30(3): 194-197. DOI: 10.3784/j.issn.1003-9961.2015.03.008
WANG Chun-rong, GUAN Heng-yun, YANG Guo-liang, ZHAO Hong, LYU Yan, LIU Lan-zheng. Epidemiology of hand foot and mouth disease caused by enterovirus 71 in Jinan,2010-2013[J]. Disease Surveillance, 2015, 30(3): 194-197. DOI: 10.3784/j.issn.1003-9961.2015.03.008
Citation: WANG Chun-rong, GUAN Heng-yun, YANG Guo-liang, ZHAO Hong, LYU Yan, LIU Lan-zheng. Epidemiology of hand foot and mouth disease caused by enterovirus 71 in Jinan,2010-2013[J]. Disease Surveillance, 2015, 30(3): 194-197. DOI: 10.3784/j.issn.1003-9961.2015.03.008

2010-2013年济南地区肠道病毒71型感染手足口病流行病学分析

Epidemiology of hand foot and mouth disease caused by enterovirus 71 in Jinan,2010-2013

  • 摘要: 目的 分析2010-2013年济南地区肠道病毒71型(EV71)感染手足口病的流行病学特征,为手足口病防控提供参考依据。方法 选取济南地区2010-2013年临床诊断为手足口病的病例为对象,采集患者发病1周内的粪便、咽拭子等标本,采用肠道病毒通用(PE)、EV71和柯萨奇病毒A组16型(Cox A16)特异性引物通过反转录-聚合酶链反应(RT-PCR)进行病原学鉴定。结果 2010-2013年接受病原学检测的手足口病患儿共3351例(包括114例重症病例),2548例检测到肠道病毒(76.04%);其中EV71阳性1001例,占阳性病例的39.29%(1001/2548)。2010-2013年EV71阳性率分别为23.51% (190/808)、39.95%(334/836)、22.12%(190/859)和33.84%(287/848);重症病例EV71阳性率为80.70%(92/114),普通病例EV71阳性率为28.08%(909/3237),两者之间差异有统计学意义(2=131.9135, P0.01);重症病例中EV71阳性率显著高于其他病毒类型 (2=245.24, P0.01)。1001例感染EV71的手足口病患儿中,男女性别比为1.60:1;病例年龄主要集中于4岁以下儿童(84.42%),尤其是1~3岁年龄组(48.65%);重症病例男女比例更高(2.83:1),年龄以3岁以下幼童为主(89.13%),其中2例死亡病例均不到1岁。结论 济南地区不同年度EV71流行强度与趋势不同,EV71是重症及死亡病例的主要病原。

     

    Abstract: Objective To understand the epidemiological characteristics of enterovirus 71(EV71) caused hand foot and mouth disease (HFMD) in Jinan from 2010 to 2013,and provide scientific evidence for prevention and control of HFMD. Methods Stool samples and pharynx swabs were collected from clinically diagnosed HFMD cases in Jinan from 2010 to 2013,and reverse transcriptas-polymerase chain reaction (RT-PCR) was conducted with universal primers within 5'untranslated region of enterovirus and VP1 region of Coxsackievirus A16 (Cox A16) and EV71 for etiological identification. Results Among the 3351 HFMD cases surveyed in Jinan during 2010-2013,including 114 severe cases, 2548 were enterovirus positive (76.04%). Of the 2548 cases, 1001 (39.29%) were EV71 positive. The annual EV71 positive rate was 23.51%, 39.95%, 22.12%, and 33.84%, respectively.The difference in EV71 positive rate was significant between severe cases (80.70%) and mild cases (28.08%) (2=131.9135, P0.01); Of the 114 severe cases, the positive rate of EV71 was significantly higher than those of other enteroviruses (2=245.24, P0.01). Among the 1001 EV71 caused HFMD cases, the male to female ratio was 1.60:1, and the age of most affected children was under 4 years (84.42%), and those aged 1-3 years accounted for 48.65%. Most severe cases (89.13%) were children aged3 years, and the male to female ratio of the severe cases was 2.83:1. The 2 fatal cases were all under 1 year old. Conclusion The circulating strength and trend of EV71 varied with year during 2010-2013; EV71 was major pathogen of severe or fatal HFMD cases.

     

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