Abstract: Objective To understand the epidemiological characteristics and drug resistance of Salmonella caused infectious diarrhea in children in Yuyao, Zhejiang province, and provide evidence for the clinical medication of Salmonella caused infectious diarrhea in children and the prevention and control of intestinal infectious diseases. Methods Stool samples were collected from children with diarrhea in foodborne disease sentinel hospital in Yuyao. The biochemical identification and serological typing of the isolates were conducted, and the drug susceptibility test was performed with K-B methods. Results A total of 26 Salmonella strains of were detected from 223 stool samples (11.65%), which belonged to 13 serotypes, Salmonella typhimurium was predominant (42.31%), followed by Salmonella derby and Salmonella stanley (7.69%). More Salmonella typhimurium strains were detected in females, the male to female ratio was 1:1.17. The infections in age groups 0-1 year and 1-2 years accounted for 50% and 38.40%, respectively. The incidence peak was during May-October. The sensitive rates to cephalosporins, quinolones, beta lactams, aminoglycosides were high. The resistant rates to penicillin, ampicillin, cotrimoxazole, piperacillin were 26.92%, 26.92%, 19.23%, 15.39% respectively. It was found that 9 strains were drug resistant, 7 strains were multi drug resistant, in which 1 Salmonella typhimurium strain was resistant to 13 antibiotics. Conclusion Salmonella infection mainly affect age group 0-2 years and more females were infected in Yuyao. The incidence peak usually occurs during May-October. Salmonella typhimurium is the predominant pathogen. Multi drug resistance detection can guide the rational use of antibiotics.