Abstract: Objective To understand the incidence of the adverse drug reactions(ADR) in multidrug resistant tuberculosis(MDR-TB) patients during anti TB treatment and compare the difference in adverse drug reaction between domestic anti TB drug and imported anti TB drug. Methods During September-December in 2015, a retrospective questionnaire survey was conducted among 195 MDR-TB patients. Results The basic information of the patients were similar, regardless they used domestic anti TB drugs or imported anti TB drugs. The suspension rate was 16.28% for domestic anti TB drugs and 15.15% for imported anti TB drugs (2=0.04, P=0.84), and 8.53% of the patients who taken domestic anti TB drugs stopped treatment, so did 6.06% of the patients who taken imported anti TB drugs(2=0.37, P=0.54), the differences had no significance. The ADR rates were 23.26% and 21.21%, respectively, in 2 groups, the difference had no significance (2=0.10, P=0.75). The first 3 ADRs were hepatotoxicity, gastrointestinal reaction,joint and muscle aches in domestic anti TB drug users, and gastrointestinal reaction, mental symptoms and anaphylaxis in imported anti TB drug users. Conclusions Though ADR is common in the treatment of MDR-TB, most treatment can continue if appropriate adjustment is made on therapeutic regimen. The safety of the domestic drugs at low dosage was similar to that of the imported drugs at high dosage. Further studies are needed on whether ADR would increase if increased dosages of the domestic drugs are used to ensure the effect of MDR-TB treatment.