2014年浙江省湖州市急性腹泻患者诺如病毒感染及基因特征研究

沈月华 纪蕾 陈莉萍 朱晓娟 查赟峰 徐德顺 吴晓芳

沈月华, 纪蕾, 陈莉萍, 朱晓娟, 查赟峰, 徐德顺, 吴晓芳. 2014年浙江省湖州市急性腹泻患者诺如病毒感染及基因特征研究[J]. 疾病监测, 2016, 31(11): 941-944. doi: 10.3784/j.issn.1003-9961.2016.11.012
引用本文: 沈月华, 纪蕾, 陈莉萍, 朱晓娟, 查赟峰, 徐德顺, 吴晓芳. 2014年浙江省湖州市急性腹泻患者诺如病毒感染及基因特征研究[J]. 疾病监测, 2016, 31(11): 941-944. doi: 10.3784/j.issn.1003-9961.2016.11.012
SHEN Yue-hua, JI Lei, CHEN Li-ping, ZHU Xiao-juan, ZHA Yun-feng, XU De-shun, WU Xiao-fang. Infection status and genetic diversity of noroviruses in patients with acute gastroenteritis in Huzhou, Zhejiang,2014[J]. Disease Surveillance, 2016, 31(11): 941-944. doi: 10.3784/j.issn.1003-9961.2016.11.012
Citation: SHEN Yue-hua, JI Lei, CHEN Li-ping, ZHU Xiao-juan, ZHA Yun-feng, XU De-shun, WU Xiao-fang. Infection status and genetic diversity of noroviruses in patients with acute gastroenteritis in Huzhou, Zhejiang,2014[J]. Disease Surveillance, 2016, 31(11): 941-944. doi: 10.3784/j.issn.1003-9961.2016.11.012

2014年浙江省湖州市急性腹泻患者诺如病毒感染及基因特征研究

doi: 10.3784/j.issn.1003-9961.2016.11.012

Infection status and genetic diversity of noroviruses in patients with acute gastroenteritis in Huzhou, Zhejiang,2014

  • 摘要: 目的 了解2014年浙江省湖州市急性腹泻患者诺如病毒感染状况及基因特征,为加强感染性腹泻监测与综合防控工作提供依据。方法 收集2014年湖州市综合性三级乙等和二级甲等各一家医院的粪便标本797份,采用实时荧光定量PCR方法进行诺如病毒核酸检测,并对诺如病毒核酸阳性标本进行衣壳蛋白区的序列测定和分析。结果 797份粪便标本中149份检出诺如病毒核酸阳性,阳性率18.70%(149/797),以GⅡ基因型为主,占89.26%(133/149)。衣壳蛋白区序列的系统进化分析显示检出的诺如病毒有5种GⅠ型别和7种GⅡ型别,包括GⅠ.1、GⅠ.2、GⅠ.5、GⅠ.6、GⅠ.7、GⅡ.2、GⅡ.3、GⅡ.4、GⅡ.6、GⅡ.8、GⅡ.17、GⅡ.21,以GⅡ.4 Sydney_2012(55.5%)、GⅡ.17(25.5%)型为主。结论 诺如病毒在湖州市急性腹泻患者中存在较高感染,并且基因型别复杂,除了流行优势型别GⅡ.4外,2014年底还出现GⅡ.17型诺如病毒的流行,因此应加强诺如病毒腹泻监测工作,为今后疫情防控提供科学依据。
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出版历程
  • 收稿日期:  2016-01-29
  • 刊出日期:  2016-11-20

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