2016年浙江省湖州市急性胃肠炎病例诺如病毒感染状况及其基因型别特征

纪蕾 陈莉萍 沈月华 严伟 吴晓芳 徐德顺 朱晓娟 查赟峰

纪蕾, 陈莉萍, 沈月华, 严伟, 吴晓芳, 徐德顺, 朱晓娟, 查赟峰. 2016年浙江省湖州市急性胃肠炎病例诺如病毒感染状况及其基因型别特征[J]. 疾病监测, 2018, 33(3): 235-240. doi: 10.3784/j.issn.1003-9961.2018.03.016
引用本文: 纪蕾, 陈莉萍, 沈月华, 严伟, 吴晓芳, 徐德顺, 朱晓娟, 查赟峰. 2016年浙江省湖州市急性胃肠炎病例诺如病毒感染状况及其基因型别特征[J]. 疾病监测, 2018, 33(3): 235-240. doi: 10.3784/j.issn.1003-9961.2018.03.016
Ji Lei, Chen Liping, Shen Yuehua, Yan Wei, Wu Xiaofang, Xu Deshun, Zhu Xiaojuan, Zha Yunfeng. Epidemiologic and genetic characteristics of norovirus caused acute gastroenteritis in Huzhou,Zhejiang,2016[J]. Disease Surveillance, 2018, 33(3): 235-240. doi: 10.3784/j.issn.1003-9961.2018.03.016
Citation: Ji Lei, Chen Liping, Shen Yuehua, Yan Wei, Wu Xiaofang, Xu Deshun, Zhu Xiaojuan, Zha Yunfeng. Epidemiologic and genetic characteristics of norovirus caused acute gastroenteritis in Huzhou,Zhejiang,2016[J]. Disease Surveillance, 2018, 33(3): 235-240. doi: 10.3784/j.issn.1003-9961.2018.03.016

2016年浙江省湖州市急性胃肠炎病例诺如病毒感染状况及其基因型别特征

doi: 10.3784/j.issn.1003-9961.2018.03.016
基金项目: 

浙江省医药卫生科技计划(No.2018RC015);湖州市自然科学基金(No.2017YZ04)

Epidemiologic and genetic characteristics of norovirus caused acute gastroenteritis in Huzhou,Zhejiang,2016

Funds: 

This study were supported by the fund for the ZheJiang Medical Science and Technology Program (No. 2018RC015) and the Natural Science Foundation of Huzhou Science and Technolgy Bureau(No. 2017YZ04)

  • 摘要: 目的 调查浙江省湖州市急性胃肠炎病例诺如病毒的感染状况、基因型别及其动态变化趋势。方法 于2016年采集湖州市食源性疾病主动监测哨点医院的急性胃肠炎病例粪便标本。采用特异性引物探针,应用real-time RT-PCR对标本进行诺如病毒核酸检测。同时对阳性标本衣壳蛋白基因片段进行扩增和测序,结合在线分型工具和序列系统进化分析诺如病毒基因型别。结果 501份急性胃肠炎患者粪便标本检出诺如病毒阳性101份,阳性率20.16%,以GⅡ基因组为主(86.14%);男性检出率为20.75%(50/241),女性检出率为19.54%(51/260),差异无统计学意义。不同年龄段病例均检出诺如病毒,5岁儿童检出率最高。诺如病毒感染全年均有发生,但6-9月呈低流行状态。2016年湖州市流行的诺如病毒基因型别多样,包括GⅡ.17、GⅡ.4 Sydney_2012、GⅡ.3、GⅡ.13、GⅠ.6、GⅡ.2、GⅡ.6、GⅠ.7共8种基因型别。GⅡ.17和GⅡ.4 Sydney_2012呈月份交替流行。结论 湖州市急性胃肠炎病例诺如病毒基因型别多样,且呈交替流行现象,应进一步加强监测各型别诺如病毒在本地的流行范围及型别分布变化情况。
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出版历程
  • 收稿日期:  2017-12-04
  • 刊出日期:  2018-03-30

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