Abstract: Objective To analyze the incidence pattern of major chronic diseases in Xiacheng district of Hangzhou from 2006 to 2011 and provide scientific evidence for the development of intervention strategies. Methods Descriptive epidemiological analysis was conducted on the incidence data of chronic diseases in Xiacheng district from 2006 to 2011 collected from public health surveillance system in Xiacheng district and coded according to ICD-10. Results From 2006 to 2011, the overall average incidence of malignant tumors, diabetes, strokes, and acute coronary heart disease events was 864.37/lakh with an annual increase of 10.37%. The incidences of the 4 diseases were higher in males than in females (2=134.67, P0.05) and the incidences increased with age. Young people were affected by these diseases too. The first 5 malignant tumors with high incidences were lung cancer, colon cancer, stomach cancer, breast cancer and liver cancer. Breast cancer has highest incidence than others among females. The proportion of diabetes complications was high, accounting for 14.47% of the total diabetes cases. Among strokes and acute coronary heart disease events, the incidences of cerbral infarction and acute myocardial infarction were highest (174.02/lakh and 34.82/lakh, respectively). Conclusion Old males have become the key population in chronic disease prevention and control, but the chronic diseases in young population should not be neglected. It is necessary to conduct targeted health education, malignant tumors screening and standard management of chronic disease cases to reduce the incidence of chronic diseases and related complications to improve the peoples life quality.