Abstract: Objective To understand the coverage of national immunization program (NIP) among local children and floating children in Taizhou, Zhejiang province. Methods Household questionnaire survey was conducted among 1954 local children selected by stratified cluster sampling in 126 villages in 63 townships in 9 counties. An face to face questionnaire survey was conducted among 256 floating children randomly selected in floating population living areas. Results The rate of vaccination certificate handling was 99.95%.The coverage rates of 1 dose of bacillus calmette-guerin (BCG), 3 doses of oral polio vaccine (OPV), 3 doses of diphtheria tetanus and pertussis combined vaccine (DTP3), the coverage of 1st dose of measles-containing vaccine (MCV) were above 95% and 3 doses of hepatitis B vaccine (HepB) above 90%. The coverage of full vaccinations of all the five vaccines was 96.56%. The coverage rates of the fourth dose of OPV and DTP,the 2nd dose of MCV and DT were all above 90% except those in Luqiao and Xianju. The coverage rates of group A meningococcal polysaccharide vaccine (MAP-A) newly included in NIP were all above 80% except that in Sanmen. The coverage rates of Japanese encephalitis vaccine (JEV) were above 80% except those in Luqiao, Xianju and Sanmen. The coverage rates of hepatitis A vaccine (HepA) were all above 90%. The coverage rates of both the 1st and 2nd dose of group A + C meningococcal polysaccharide vaccine (MAP-A + C) were low, only 87.19% and 49.45% respectively and there were significant differences among different counties. The age specific differences in coverage rates of BCG, 1st dose OPV, 3rd dose OPV and 3rd dose DTP, in booster coverage rates of 4th dose OPV, 4th dose DTP and 2nd dose MCV and in coverage rates of 2 dose MAP-A, 1 dose MAP-A + C and 2 dose JEV among different age groups had statistical significance. The differences in coverage rates of BCG, 2nd dose DTP, 2 dose HepB, 2nd dose MCV, 4 dose DTP, 2 dose JEV and 2 dose MAP-A + C and timely of immunization rate of 1st dose HepB and 1st dose MCV between local and floating children were statistical significant, and the coverage rates in local children were higher than those in floating children. Conclusion The coverage rates of basic immunization and booster immunization of the vaccines routinely used remained at higher level, but the coverage rates of the vaccines newly included in NIP were relatively low. The differences in the coverage of booster immunization of routinely used vaccines and the vaccines newly included in NIP among different age groups and between local and floating children were statistical significant. The coverage rates declined with the increase of age, and the coverage rates in local children were higher than those in floating children.