云南省德宏州成人艾滋病病毒感染者中乙型病毒性肝炎病毒合并感染研究

叶润华; 张玉成; 唐仁海; 杨跃诚; 姚仕堂; 王译葵; 王继宝; 杜本丽; 聂永英; 杨盈波; 韩文香; 李维美; 段松; 何纳

doi:10.3784/j.issn.1003-9961.2016.05.012

云南省德宏州成人艾滋病病毒感染者中乙型病毒性肝炎病毒合并感染研究

Co-infection of HBV among HIV-infected adults in Dehong, Yunnan

摘要

摘要: 目的了解云南省德宏州艾滋病病毒(HIV)感染者中乙型病毒性肝炎(乙肝)病毒(HBV)合并感染率,并分析其影响因素。方法对德宏州HIV感染者进行横断面调查,进行乙肝五项指标检测。结果在进行乙肝五项指标检测的5732例HIV感染者中,共有486例(8.5%)乙肝表面抗原(HBsAg)阳性,2737例(47.7%)乙肝表面抗体(HBsAb)阳性,102例(1.8%)乙肝e抗原(HBeAg)阳性,522例(9.1%)乙肝e抗体(HBeAb)阳性,3727例(65.0%)乙肝核心抗体(HBcAb)阳性,90例(1.6%)感染者为乙肝大三阳(HBsAg、HBeAg和HBcAb三项阳性)。多因素logistic回归分析显示,18～29岁年龄组大三阳阳性率高于50岁以上年龄组(OR=3.04,95%CI:1.30～7.15);男性大三阳阳性率高于女性(OR=1.77,95%CI:1.06～2.95)。结论德宏州HIV感染者中存在一定比例的HBV合并感染者;不同特征HIV感染者,HBV合并感染率不同。

Abstract: Objective To understand the prevalence of hepatitis B virus (HBV) infection and related risk factors among HIV-infected adults in Dehong, Yunnan province. Methods A cross-sectional study was carried out among HIV-infected adults in Dehong and serum tests were performed to detect HBV infection related markers. Results A total of 5732 HIV infected adults were included in this study, the positive rates of HBsAg, HBsAb, HBeAg, HBeAb, HBcAb were 8.5%, 47.7%, 1.8%, 9.1%, and 65.0%, respectively. The positive rate of HBsAg, HBeAg and HBcAb was 1.6%, Multivariate logistic regression analysis indicated that the risk of HBV infection was higher in those aged 18-29 years than in those aged 50 years (OR=3.04,95% CI:1.30-7.15), in males than in females (OR=1.77,95% CI:1.06-2.95) among the HIV infected adults surveyed. Conclusion The co-infection of HBV was prevalent in HIV-infected adults in Dehong and related with demographic characteristics.

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